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KMID : 0882420160900030258
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Korean Journal of Medicine
2016 Volume.90 No. 3 p.258 ~ p.261
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Successful Treatment of Relapsed Acquired Amegakaryocytic Thrombocytopenia with Repeat Cyclosporine
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배수야:Bae Soo-Ya
한태희:Han Tae-Hee/손병석:Sohn Byeong-Seok/오현호:Oh Hyun-Ho/최성진:Choi Seong-Jin/박문:Park Moon/유영진:Yuh Young-Jin
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Abstract
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Acquired amegakaryocytic thrombocytopenia (AAMT) is an unusual disease characterized by severe thrombocytopenia resulting from a marked decrease in bone marrow megakaryocytes. Various pathogenic mechanisms have been suggested, and several treatments have been tried, with varying outcomes. In some case reports, cyclosporine and anti-thymocyte globulin have had good clinical results in the treat of AAMT. There are few reports on the treatment of relapsed AAMT with cyclosporine. We report a patient with relapsed AAMT who was treated successfully with an additional course of cyclosporine. The initial remission was achieved with cyclosporine 4 years earlier and a second remission was induced by cyclosporine. Cyclosporine may be effective for relapsed AAMT that previously responded to cyclosporine.
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KEYWORD
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Acquired amegakaryocytic thrombocytopenia, Cyclosporine
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